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Cited 6 time in webofscience Cited 6 time in scopus
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No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patientsopen access

Authors
Kim, Il-SooYoon, Ho-KyoungKang, Seung-GulPark, Young-MinKim, Yong-KuKim, Seung-HyunChoi, Jung-EunKim, LeenLee, Heon-Jeong
Issue Date
Jun-2012
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Schizophrenia; Tardive dyskinesia; PAWR; Polymorphism
Citation
PSYCHIATRY INVESTIGATION, v.9, no.2, pp.191 - 194
Indexed
SCIE
SSCI
SCOPUS
KCI
Journal Title
PSYCHIATRY INVESTIGATION
Volume
9
Number
2
Start Page
191
End Page
194
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12012
DOI
10.4306/pi.2012.9.2.191
ISSN
1738-3684
Abstract
Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD. Psychiatry Investig 2012;9:191-194
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Kim, Yong Ku
안산병원 (Department of Psychiatry, Ansan Hospital)
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