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Cited 37 time in webofscience Cited 40 time in scopus
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Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection

Authors
Choi, Hyuk SoonChun, Hoon JaiPark, Sang HoonKeum, BoraSeo, Yeon SeokKim, Yong SikJeen, Yoon-TaeUm, Soon HoLee, Hong SikKim, Chang DuckRyu, Ho Sang
Issue Date
May-2012
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
Helicobacter pylori; Sequential therapy; Triple therapy; Gastric ulcer; Duodenal ulcer; Gastritis
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.18, no.19, pp.2377 - 2382
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
18
Number
19
Start Page
2377
End Page
2382
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12086
DOI
10.3748/wjg.v18.i19.2377
ISSN
1007-9327
Abstract
AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients. (c) 2012 Baishideng. All rights reserved.
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Anam Hospital (Department of Internal Medicine, Anam Hospital)
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