Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection
- Authors
- Choi, Hyuk Soon; Chun, Hoon Jai; Park, Sang Hoon; Keum, Bora; Seo, Yeon Seok; Kim, Yong Sik; Jeen, Yoon-Tae; Um, Soon Ho; Lee, Hong Sik; Kim, Chang Duck; Ryu, Ho Sang
- Issue Date
- May-2012
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- Helicobacter pylori; Sequential therapy; Triple therapy; Gastric ulcer; Duodenal ulcer; Gastritis
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.18, no.19, pp 2377 - 2382
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 18
- Number
- 19
- Start Page
- 2377
- End Page
- 2382
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12086
- DOI
- 10.3748/wjg.v18.i19.2377
- ISSN
- 1007-9327
2219-2840
- Abstract
- AIM: To compare the effectiveness of sequential therapy for Helicobacter pylori (H. pylori) infection with that of triple therapy of varying durations. METHODS: The 460 patients enrolled in this study had H. pylori-associated gastritis or a gastric or duodenal ulcer. After screening, H. pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7, 10 or 14 d, or a new 10-d sequential therapy. Each of the 4 treatment groups included 115 patients. The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology. RESULTS: The overall eradication rate was 81.0%, and eradication rates were 75.7% for 7-d conventional triple therapy, 81.9% for 10-d conventional triple therapy, 84.4% for 14-d conventional triple therapy, and 82.0% for 10-d sequential therapy. Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P = 0.416 and P = 0.405, respectively). CONCLUSION: There are no significant differences between 10-d sequential eradication therapy for H. pylori and any duration of standard triple treatment in Korean patients. (c) 2012 Baishideng. All rights reserved.
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- Appears in
Collections - 2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
- 5. Others > Others(Medicine) > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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