Detailed Information

Cited 0 time in webofscience Cited 10 time in scopus
Metadata Downloads

Optimal time for repeating the IgM anti-hepatitis A virus antibody test in acute hepatitis A patients with a negative initial test.

Authors
Hyun J.J.Seo Y.S.An H.Yim S.Y.Seo M.H.Kim H.S.Kim C.H.Kim J.H.Keum B.Kim Y.S.Yim H.J.Lee H.S.Um S.H.Kim C.D.Ryu H.S.
Issue Date
Mar-2012
Keywords
Acute hepatitis A; IgM anti-HAV; Alanine aminotransferase
Citation
The Korean journal of hepatology, v.18, no.1, pp.56 - 62
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of hepatology
Volume
18
Number
1
Start Page
56
End Page
62
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12724
DOI
10.3350/kjhep.2012.18.1.56
ISSN
2093-8047
Abstract
The nonspecific clinical presentation of acute hepatitis A (AHA) mandates the detection of anti-hepatitis A virus IgM antibodies (IgM anti-HAV) in the serum for obtaining a definitive diagnosis. However, IgM anti-HAV might not be present during the early phase of the disease. The aim of this study was to determine the optimal time for repeating the IgM anti-HAV test (HAV test) in AHA patients with a negative initial test. In total, 261 patients hospitalized with AHA were enrolled for this retrospective study. AHA was diagnosed when the test for IgM anti-HAV was positive and the serum alanine aminotransferase (ALT) level was ≥400 IU/L. Repeat HAV test was conducted after 1-2 weeks if the initial HAV test was negative but AHA was still clinically suspected. The results of the initial HAV test were negative in 28 (10.7%) patients. The intervals from symptom onset to the initial-HAV-test day and from the peak-ALT day to the initial-HAV-test day were significantly shorter in the negative-initial-HAV-test group, but on multivariate analysis only the latter was significantly associated with negative results for the initial HAV test (β=-0.978; odds ratio [95% confidence interval]=0.376 [0.189-0.747]; P=0.005). The HAV test was positive in all patients when it was performed at least 2 days after the peak-ALT day. The results of HAV tests were significantly associated with the interval from the peak-ALT day to the HAV-test day. The optimal time for repeating the HAV test in clinically suspicious AHA patients with a negative initial HAV test appears to be at least 2 days after the peak-ALT day.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Keum, Bora photo

Keum, Bora
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE