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Cited 22 time in webofscience Cited 25 time in scopus
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Effect of Helicobacter pylori Eradication on the Development of Reflux Esophagitis and Gastroesophageal Reflux Symptoms: A Nationwide MultiCenter Prospective Studyopen access

Authors
Kim, NayoungLee, Sang WooKim, Jin IlBaik, Gwang HoKim, Sung JungSeo, Geom SeogOh, Hyo JeongKim, Sang WookJeong, HeyjinHong, Su JinShim, Ki-NamShin, Jeong EunPark, Seun JaIm, Eui HyeogPark, Jong-JaeCho, Sung-IlJung, Hyun Chae
Issue Date
Dec-2011
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Helicobacter pylori; Eradication; Reflux esophagitis; Symptoms
Citation
GUT AND LIVER, v.5, no.4, pp.437 - 446
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
GUT AND LIVER
Volume
5
Number
4
Start Page
437
End Page
446
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12959
DOI
10.5009/gnl.2011.5.4.437
ISSN
1976-2283
Abstract
Background/Aims: A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population. Methods: In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms. Results: RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylorinegative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age >= 60 years (odds ratio [OR], 7.11; 95% confidence interval [Cl], 1.92 to 26.41), alcohol consumption (OR, 4.43; 95% Cl, 1.03 to 19.19) and F/U cholesterol levels >= 200 mg/dL (OR, 5.03; 95% Cl, 1.32 to 19.17) were significant risk factors for the development of RE. There was no significant difference in the development of GERD symptoms or weight according to H. pylori status during the 2-year F/U. Conclusions: Eradication of H. pylori did not affect the development of reflux esophagitis or GERD symptoms among patients in outpatient gastroenterology clinics in South Korea. (Gut Liver 2011;5:437-446)
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Lee, Sang Woo
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
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