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Changes in the arginine methylation of organ proteins during the development of diabetes mellitus
- Issue Date
- Oct-2011
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Diabetes mellitus; Arginine methylation; Asymmetric dimethylarginine; Dimethylarginine dimethylaminohydrolase; Nitric oxide synthase
- Citation
- DIABETES RESEARCH AND CLINICAL PRACTICE, v.94, no.1, pp 111 - 118
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Volume
- 94
- Number
- 1
- Start Page
- 111
- End Page
- 118
- ISSN
- 0168-8227
1872-8227
- Abstract
- Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52 kDa in liver tissue and at 38 and 25 kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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Related Researcher
- Park, Gil Hong
- College of Medicine (Department of Biochemistry and Molecular Biology)