Sentinel Node Identification Using Technetium-99m Neomannosyl Human Serum Albumin in Esophageal Cancer
- Authors
- Kim, Hyun Koo; Kim, SeungEun; Park, Jong Jae; Jeong, Jae Min; Mok, Young Jae; Choi, Young Ho
- Issue Date
- May-2011
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- ANNALS OF THORACIC SURGERY, v.91, no.5, pp 1517 - 1522
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- ANNALS OF THORACIC SURGERY
- Volume
- 91
- Number
- 5
- Start Page
- 1517
- End Page
- 1522
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13526
- DOI
- 10.1016/j.athoracsur.2011.01.016
- ISSN
- 0003-4975
1552-6259
- Abstract
- Background. This study is a clinical trial designed to test the reliability and feasibility of sentinel node detection using a new mannose receptor radioactive binding agent in patients with esophageal squamous cell carcinoma. Methods. Twenty-three patients (21 men, 2 women; mean age 61.0 +/- 8.60 years) who were candidates for esophagectomy with conventional lymph node dissection for thoracic esophageal cancer were enrolled. A total dose of 1mCi of (99m)Tc-MSA [technetium-99m neomannosyl human serum albumin] in 0.2 mL was administered at 4 quadrants into the submucosal layer around the primary tumor under esophagoscopic guidance approximately 1 hour before surgery. Intraoperative sentinel node sampling was subsequently followed by esophagectomy. All harvested lymph nodes were cut into 2-mm slices and ultimately diagnosed using formalin-fixed and paraffin-embedded sections with hematoxylin and eosin staining. Results. The number of dissected lymph nodes per patient was 30.5 +/- 9.18 (15-47). Among 23 patients, the sentinel lymph nodes could be identified in 21 patients (91.3%). The sentinel nodes could be identified in all 21 patients with cT1 or T2N0M0 (100%) disease; these patients were candidates for sentinel lymph node navigation surgery for the esophageal cancer. The mean number of sentinel nodes identified was 2.6 +/- 1.35 (range, 1-5) per patient. No false-negative sentinel lymph nodes were detected in any of the 8 patients with node-positive disease (0%). Conclusions. Intraoperative sentinel lymph node identification using (99m)Tc-MSA was feasible and reliable in patients with esophageal squamous cell carcinoma.
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- Appears in
Collections - 2. Clinical Science > Department of Foregut Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
- 2. Clinical Science > Department of Nuclear Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Thoracic and Cardiovascular Surgery > 1. Journal Articles
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