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Cited 7 time in webofscience Cited 6 time in scopus
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Virologic and biochemical responses to clevudine in patients with chronic HBV infection- associated cirrhosis: data at week 48

Authors
Kim, J. H.Yim, Hyung JoonJung, E. S.Jung, Y. K.Kim, J. H.Seo, Y. S.Yeon, J. E.Lee, H. S.Um, S. H.Byun, K. S.
Issue Date
Apr-2011
Publisher
Blackwell Publishing Inc.
Keywords
biochemical response; clevudine; liver cirrhosis; virologic response
Citation
Journal of Viral Hepatitis, v.18, no.4, pp.287 - 293
Indexed
SCIE
SCOPUS
Journal Title
Journal of Viral Hepatitis
Volume
18
Number
4
Start Page
287
End Page
293
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13590
DOI
10.1111/j.1365-2893.2010.01304.x
ISSN
1352-0504
Abstract
Clevudine shows high rates of virologic and biochemical responses in patients with chronic hepatitis B. However, the efficacy and safety of clevudine in patients with cirrhosis are unknown. The aims of this study were to evaluate the safety and to assess the virologic and the biochemical responses to clevudine in patients with cirrhosis with chronic hepatitis B virus (HBV) infection. We reviewed data from treatment-naive patients with chronic hepatitis B with and without cirrhosis who started clevudine between April 2007 and March 2008 (n = 52, hepatitis B without cirrhosis n = 21 and chronic hepatitis B with cirrhosis n = 31) at Korea University Ansan/Guro Hospital. All of the patients were treated for more than 48 weeks. The mean age was older in the patients with cirrhosis. Baseline HBV DNA levels were 6.9 and 7.78 log copies/mL (P = 0.042), and alanine aminotransferase (ALT) levels were 104.9 and 147.4 IU/L (P = 0.204), for those with and without cirrhosis, respectively. Virologic response (HBV DNA < 1000 copies/mL) (87.1%vs 71.4%, P = 0.24) and biochemical response (83.9%vs 80.9%, P = 0.99) at week 48 were not significantly different between the two groups. Early virologic response at week 12 was even higher in the patients with cirrhosis (61.3%vs 28.6%, P = 0.026). Neither ALT flare nor newly onset hepatic decompensation was found in the patients with cirrhosis, whereas ALT flare was transiently observed in 14.3% of the chronic hepatitis group. In conclusion, although clevudine may produce a transient elevation of ALT during the early treatment period, such findings were not observed in patients with cirrhosis and the virologic and biochemical responses of the groups were comparable.
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Kim, Ji Hoon
구로병원 (Department of Gastroenterology and Hepatology, Guro Hospital)
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