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Cited 4 time in webofscience Cited 4 time in scopus
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Clinical Significance of a Large Difference (>= 2 points) between Biopsy and Post-prostatectomy Pathological Gleason Scores in Patients with Prostate Canceropen access

Authors
Yoo, ChangheeOh, Cheol YoungCho, Jin SeonSong, CherynSeo, Seong IlAhn, HanjongHwang, Tae-KonCheon, JunLee, Kang HyunKwon, Tae GyunJung, Tae YoungChung, Moon KeeLee, Sang EunLee, Hyun MooLee, Eun SikChoi, Young DeukChung, Byung HaKim, Hyung JinKim, Wun-JaeByun, Seok-SooChoi, Han Yong
Issue Date
Apr-2011
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Prostatic Neoplasms; Gleason Score; Prognosis
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.4, pp 507 - 512
Pages
6
Indexed
SCI
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
26
Number
4
Start Page
507
End Page
512
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13595
DOI
10.3346/jkms.2011.26.4.507
ISSN
1011-8934
1598-6357
Abstract
We investigated the clinical significance of large difference (>= points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS >= 2, n = 30), B (changed in pGS <= n = 1,361; control group), and C (increased in pGS >= n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.
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