Red Ginseng Extract Improves Coronary Flow Reserve and Increases Absolute Numbers of Various Circulating Angiogenic Cells in Patients with First ST-Segment Elevation Acute Myocardial Infarction
- Authors
- Ahn, Chul Min; Hong, Soon Jun; Choi, Seung Cheol; Park, Jae Hyung; Kim, Jae Sang; Lim, Do-Sun
- Issue Date
- Feb-2011
- Publisher
- WILEY
- Keywords
- red ginseng extract; acute myocardial infarction; coronary flow reserve; stem cell
- Citation
- PHYTOTHERAPY RESEARCH, v.25, no.2, pp 239 - 249
- Pages
- 11
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 25
- Number
- 2
- Start Page
- 239
- End Page
- 249
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13716
- DOI
- 10.1002/ptr.3250
- ISSN
- 0951-418X
1099-1573
- Abstract
- The effects of red ginseng extract on circulating angiogenic cell mobilization and improvement of microvascular integrity were evaluated in ST-elevation acute myocardial infarction (AM I) patients during 8-month follow-up. AMI patients (n = 50) were randomly assigned to the red ginseng group (3 g/day, n = 25) or the placebo group (n = 25) after coronary stenting. Coronary flow reserve (CFR) was measured at baseline and at 8 months with an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34(+), CXCR4(+), CD117(+), CD133(+) and C-met(+) were measured at baseline, 1 day, 5 days and at 8 months. CFR were similar between the two groups at baseline, and CFR was significantly higher in the red ginseng group than in the placebo group (2.80 +/- 0.91 and 2.56 +/- 0.77, p < 0.05, respectively) after 8 months of red ginseng administration. The absolute numbers of circulating CD34(+), CXCR4(+) and CD117(+) cells were significantly higher in the red ginseng group at 1 and 5 days after stenting. Significant positive correlations were found between the numbers of circullating angiogenic cells at day 1 and the changes from baseline in CFR for CD34(+), CXCR4(+), CD117(+) and C-met cells. Red ginseng extract increased CD34(+), CXCR4(+) and CD117(+) circulating angiogenic cell mobilization and decreased inflammation in AMI patients, thereby improving CFR during the 8-month follow-up. Copyriight (C) 2010 John Wiley & Sons, Ltd.
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- Appears in
Collections - 4. Research institute > Metabolic Syndrome Research Center > 1. Journal Articles
- 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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