The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model
- Authors
- Kim, Chang Min; Kim, Bo Young; Suh, Dong Hye; Lee, Sang Jun; Moon, Hye Rim; Ryu, Hwa Jung
- Issue Date
- Dec-2019
- Publisher
- Blackwell Publishing Inc.
- Keywords
- collagen; polydioxanone; poly-L-lactic acid
- Citation
- Journal of Cosmetic Dermatology, v.18, no.6, pp 1893 - 1898
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Cosmetic Dermatology
- Volume
- 18
- Number
- 6
- Start Page
- 1893
- End Page
- 1898
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1398
- DOI
- 10.1111/jocd.12894
- ISSN
- 1473-2130
1473-2165
- Abstract
- Background
There are many collagen-stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly-L-lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread-lifting material due to its collagen-forming effects. PDO in powdered form is expected to be a good material for collagen-producing fillers.
Objectives
To evaluate the collagen-producing effects of powdered PDO injection compared with PLLA injection in a murine model.
Materials and Methods
Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate-buffered saline was injected on dorsal skin of 8-week-old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real-time PCR to quantify collagen and tissue growth factors.
Results
Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF-β1, TGF-β2, and TGF-β3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA.
Conclusion
Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Dermatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.