Safety of ultra-rapid intravenous infusion of hepatitis B immunoglobulin in liver transplant recipients
- Authors
- Hwang S.; Yu Y.D.; Park G.C.; Choi Y.I.; Park P.J.; Jung S.W.; Namgoong J.M.; Yoon S.Y.; Ha H.S.; Hong J.J.; Kim I.O.; Jeon M.K.; Ma J.E.; Choi S.Y.; Yun J.S.; Jung D.H.; Song G.W.; Ha T.Y.; Moon D.B.; Kimy K.H.; Ahn C.S.; Lee S.G.
- Issue Date
- 2011
- Citation
- Transplantation Proceedings, v.43, no.5, pp 1780 - 1782
- Pages
- 3
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Transplantation Proceedings
- Volume
- 43
- Number
- 5
- Start Page
- 1780
- End Page
- 1782
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14095
- DOI
- 10.1016/j.transproceed.2011.02.013
- ISSN
- 0041-1345
1873-2623
- Abstract
- Purpose: To evaluate the safety of institutional protocol for ultra-rapid hepatitis B immunoglobulin (HBIG) infusion (10,000 IU in 30 minutes) for hepatitis B virus prophylaxis in adult liver transplant recipients. Methods: In this case-controlled study, prospectively recruited liver transplant recipients received ultra-rapid infusions of HBIG (10,000 units in 30 minutes) for 6 months. The historical control group consisted of patients who had received 1-hour HBIG infusions (conventional rapid infusion) for the precedent 6 months. Results: We found that 1472 patients had received 5744 ultra-rapid HBIG infusions, whereas 1343 patients had received 5200 conventional rapid HBIG infusions. Adverse side-effects were observed after 7 (0.13%) and 9 (0.16%) infusions, respectively (P = .763). The number of infusions per month increased significantly, from 878 ± 34 before the introduction of ultra-rapid infusion to 957 ± 29 afterwards (P < .001), an increase of 10.5%. The maximal capacity of HBIG infusions per day in the outpatient clinic increased from 53 for conventional rapid infusion to 65 for ultra-rapid infusion, without expansion of the outpatient facility or equipment. Conclusions: Nearly all adult liver recipients able to tolerate 1-hour infusions of HBIG can also tolerate ultra-rapid infusions well. Thus, it seems to be reasonable to perform ultra-rapid infusion protocol widely for patient convenience. © 2011 Elsevier Inc.
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- Appears in
Collections - 2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles
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