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Cited 9 time in webofscience Cited 15 time in scopus
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Healing Effects of Rebamipide and Omeprazole in Helicobacter pylori-Positive Gastric Ulcer Patients after Eradication Therapy: A Randomized Double-Blind, Multinational, Multi-Institutional Comparative Study

Authors
Song, Kyung HoLee, Yong ChanFan, Dai-MingGe, Zhi-ZhengJi, FengChen, Min-HuJung, Hyun ChaeBo, JiangLee, Sang WooKim, Jin-Ho
Issue Date
2011
Publisher
KARGER
Keywords
Gastric ulcer; Helicobacter pylori; Omeprazole; Proton pump inhibitor; Rebamipide; Treatment efficacy
Citation
DIGESTION, v.84, no.3, pp.221 - 229
Indexed
SCIE
SCOPUS
Journal Title
DIGESTION
Volume
84
Number
3
Start Page
221
End Page
229
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14153
DOI
10.1159/000329353
ISSN
0012-2823
Abstract
Background and Aims: A recent placebo-controlled trial showed that rebamipide, which is a mucosal-protective antiulcer agent, promoted gastric ulcer healing without affecting the Helicobacter pylori status. We conducted a randomized, double-blind trial to compare the healing effects of rebamipide and the proton-pump inhibitor omeprazole in H. pylori-positive gastric ulcers after H. pylori eradication therapy. Methods: After completion of 1 week of eradication therapy, 132 patients with H. pylori-positive gastric ulcer were enrolled in 5 Chinese and 4 Korean institutions. Patients were randomly assigned to take either 20 mg of omeprazole (n = 63) or 300 mg of rebamipide (n = 65) daily for 7 weeks. Healing was defined as complete recovery and S1 and S2 stage ulcer according to the Sakita-Miwa classification. Results: Healing rates at 12 weeks were 81.5% (53/65) and 82.5% (52/63) in the rebamipide and omeprazole groups, respectively. There was no significant difference in treatment efficacy, as evidenced by gastric ulcer healing rates (absolute difference -1.0%; 95% confidence interval -10.7 to 8.7; p = 0.88). The H. pylori eradication rate and ulcer healing rate did not differ between the groups, the latter regardless of eradication outcome. Conclusions: Rebamipide is as effective as omeprazole in treating of H. pylori-positive gastric ulcer after eradication therapy. Copyright (C) 2011 S. Karger AG, Basel
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Lee, Sang Woo
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
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