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Cited 39 time in webofscience Cited 37 time in scopus
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Comparison of Surrogate Serum Markers and Transient Elastography (Fibroscan) for Assessing Cirrhosis in Patients with Chronic Viral Hepatitis

Authors
Lee, Myoung HeeCheong, Jae YounUm, Soon HoSeo, Yeon SeokKim, Dong JoonHwang, Seong GyuYang, Jin MoHan, Kwang-HyubCho, Sung Won
Issue Date
Dec-2010
Publisher
SPRINGER
Keywords
Cirrhosis; Serum markers; Elastography; Platelet; PIIINP
Citation
DIGESTIVE DISEASES AND SCIENCES, v.55, no.12, pp.3552 - 3560
Indexed
SCIE
SCOPUS
Journal Title
DIGESTIVE DISEASES AND SCIENCES
Volume
55
Number
12
Start Page
3552
End Page
3560
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14296
DOI
10.1007/s10620-010-1219-0
ISSN
0163-2116
Abstract
Progressive hepatic fibrosis with development of cirrhosis is a feature of almost all chronic liver diseases. We assessed the performance of Fibroscan in patients with chronic viral hepatitis, and in comparison with and combined with several surrogate serum markers for predicting cirrhosis. In this prospective multicenter cohort study, a novel panel of serum markers was constructed and serum levels of surrogate markers of liver fibrosis and Fibroscan were compared with the stage of fibrosis in the liver biopsy specimens obtained from 121 subjects with chronic viral hepatitis. Another 159 patients were enrolled to validate the diagnostic accuracy of this novel panel. Multivariate analysis identified platelet count and procollagen III N-terminal peptide (PIIINP) as independent predictors of liver cirrhosis. The PP score (combining of platelet count and PIIINP) showed significantly better diagnostic accuracy (areas under the receiver operating characteristic curves, AUROC: 0.885) than that of previously reported serologic tests, including APRI, Forns fibrosis index, FIB-4 index and ELF algorithm, in the validation group (AUROC: 0.792, 0.740, 0.800, and 0.775, respectively). The AUROC of Fibroscan was 0.743 and the best performance was obtained by combining Fibroscan, platelet count and PIIINP, with an AUROC of 0.826. However, there was no significant difference among the AUROCs of Fibroscan alone, PP score, the combination of Fibroscan and PP score, and previously reported serologic tests in the estimation group. Fibroscan and surrogate serum markers had similar accuracy for predicting cirrhosis, and combining Fibroscan and serum markers did not improve the accuracy.
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Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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