Identification of Markers Associated With Development of Stroke in "Clinically Low-Risk" Atrial Fibrillation Patientsopen access
- Authors
- Shin, Seung Yong; Han, Sang-Jin; Kim, Jin-Seok; Im, Sung Il; Shim, Jaemin; Ahn, Jinhee; Lee, Eun Mi; Park, Yae Min; Kim, Jun Hyung; Lip, Gregory Y. H.; Lim, Hong Euy
- Issue Date
- Nov-2019
- Publisher
- Wiley-Blackwell
- Keywords
- ABCD score; atrial fibrillation; risk score; risk stratification; stroke, ischemic
- Citation
- Journal of the American Heart Association, v.8, no.21
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of the American Heart Association
- Volume
- 8
- Number
- 21
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1433
- DOI
- 10.1161/JAHA.119.012697
- ISSN
- 2047-9980
2047-9980
- Abstract
- Background
Stroke and thromboembolic events may still occur in “clinically low‐risk” atrial fibrillation (AF) patients as categorized by CHA2DS2‐VASc score. Our aim was to assess the proportion of “clinically low‐risk” patients using a nongender CHA2DS2‐VASc (ie, CHA2DS2‐VA) score of 0 to 1 among patients who experienced AF‐associated stroke and to identify markers associated with stroke in “clinically low‐risk” patients.
Methods and Results
We retrospectively recruited nonvalvular AF patients who experienced embolic stroke between 2013 and 2016 from 9 institutes in Korea. AF patients with CHA2DS2‐VA score of 0 to 1 at the time of stroke were analyzed and compared with “clinically low‐risk” AF patients without stroke. A total of 3033 subjects with AF‐associated stroke were recruited. Of these, 583 patients (19.2%) had CHA2DS2‐VA score of 0 to 1. On multivariate analysis, age (≥60 years), N‐terminal pro B‐type natriuretic peptide (≥300 pg/mL), creatinine clearance (<50 mL/min), and left atrial dimension (≥45 mm) were independently associated with stroke. With the combined application of these 4 factors (collectively, ABCD score) to the “clinically low‐risk” patients, the c‐index was 0.858 (95% CI 0.838–0.877; P<0.001).
Conclusions
The present study suggests a new insight into how additional use of markers can further refine stroke risk differentiation among AF patients initially classified as “clinically low‐risk.”
Clinical Trial Registration
URL: http://www.clinicaltrials.gov. Unique identifier: NCT03147911.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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