Detailed Information

Cited 46 time in webofscience Cited 51 time in scopus
Metadata Downloads

The role of Tregs and CD11c(+) macrophages/dendritic cells in ischemic preconditioning of the kidney

Authors
Cho, Won YongChoi, Hye MinLee, So YoungKim, Myung GyuKim, Hyoung-KyuJo, Sang-Kyung
Issue Date
Nov-2010
Publisher
NATURE PUBLISHING GROUP
Keywords
dendritic cell; immune cell; ischemic preconditioning; liposome clodronate; regulatory T cell
Citation
KIDNEY INTERNATIONAL, v.78, no.10, pp.981 - 992
Indexed
SCIE
SCOPUS
Journal Title
KIDNEY INTERNATIONAL
Volume
78
Number
10
Start Page
981
End Page
992
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14364
DOI
10.1038/ki.2010.266
ISSN
0085-2538
Abstract
Dendritic cells have the potential to induce tolerance and here we attempted to identify their role in the tolerance seen in ischemic pre-conditioning. We induced bilateral renal ischemic preconditioning in mice and then challenged them with an ischemic insult 7 days later. Compared to sham-operated controls, preconditioned mice were found to have reduced injury with less inflammation, but had an increased number of regulatory T cells (Tregs) in their kidneys after the delayed insult. Splenocytes from these mice had more Tregs and mature CD11c(+) cells, but reduced proliferative and cytokine-secretory responses, suggesting a state of immunosuppression compared to control mice. Anti-CD25 depletion followed by adoptive transfer of Tregs partially mitigated and then restored the protective effect of preconditioning. Depletion of CD11c(+) cells with liposomes containing clodronate was associated with partial loss of preconditioning benefits. The increased numbers of Tregs or impaired immune response found in splenocytes from preconditioned mice were partially reversed in splenocytes from liposome clodronate-treated animals, suggesting that CD11c(+) cells contribute to immune cell-mediated ischemic preconditioning. Hence, our results show that ischemic preconditioning of the kidney provides a negative signal to the peripheral immune system, partially mediating the tissue-protective and anti-inflammatory effects of this maneuver.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Hyoung Kyu photo

Kim, Hyoung Kyu
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE