Associations between paraoxonase-1 and systemic lupus erythematosus
- Authors
- Bae, Sang Cheol; Lee, Young Ho
- Issue Date
- Nov-2019
- Publisher
- SAGE Publications
- Keywords
- PON1; polymorphism; systemic lupus erythematosus
- Citation
- Lupus, v.28, no.13, pp 1571 - 1576
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Lupus
- Volume
- 28
- Number
- 13
- Start Page
- 1571
- End Page
- 1576
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1441
- DOI
- 10.1177/0961203319884653
- ISSN
- 0961-2033
1477-0962
- Abstract
- Objective
The objective of this analysis was to explore associations between paraoxonase-1 levels, gene polymorphisms and systemic lupus erythematosus.
Methods
Meta-analyses of paraoxonase-1 levels and Q192R and L55M and polymorphisms in systemic lupus erythematosus were conducted.
Results
Nine articles were incorporated in our meta-analysis, which uncovered that the paraoxonase-1 level was decreased in systemic lupus erythematosus compared to control (standard mean difference = −1.626, 95% confidence interval = −2.829–−0.424, p = 0.008). Ethnicity-specific meta-analysis demonstrated a relation tendency between decreased paraoxonase-1 activity and lupus in Europeans (standard mean difference = −1.236, 95% confidence interval = −2.634–0.163, p = 0.083). Paraoxonase-1 activity was reduced in systemic lupus erythematosus in a single Arab and African population. Decreased paraoxonase-1 activity was found in a small sample of systemic lupus erythematosus patients (standard mean difference = −1.642, 95% confidence interval = −3.076–−0.247, p = 0.021). Ethnicity-specific analysis indicated a relationship between the paraoxonase-1 55 M allele in the Arab systemic lupus erythematosus population. However, a lack of association with systemic lupus erythematosus and the paraoxonase-1 192 R allele was observed.
Conclusions
Meta-analyses revealed reduced paraoxonase-1 activity in patients with systemic lupus erythematosus and found possible associations between systemic lupus erythematosus and paraoxonase-1 L55M polymorphism in a specific ethnic group.
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- Appears in
Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
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