Placenta Derived Mesenchymal Stem Cells in Combination with Polycaprolactone-20% Tricalcium Phosphate Scaffolds for the Treatment of Critical-Sized Defects of the Mandible
- Authors
- Lee, Eui Seok; Seo, Byoung Moo; Rim, Jae Suk; Jang, Hyon Seok; Kwon, Jong Jin
- Issue Date
- Aug-2010
- Publisher
- KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
- Keywords
- placenta; mesenchymal stem cells; PCL-TCP scaffold; bone regeneration
- Citation
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.7, no.3, pp 276 - 282
- Pages
- 7
- Indexed
- SCIE
SCOPUS
KCICANDI
- Journal Title
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- Volume
- 7
- Number
- 3
- Start Page
- 276
- End Page
- 282
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14622
- ISSN
- 1738-2696
2212-5469
- Abstract
- Objectives: Polycaprolactone-20% tricalcium phosphate (PCL-TCP) polymers allow for cellular adherence'and differentiation and are adequate scaffolds for bone regeneration in tissue engineering strategies The placenta contains multipotent stern cells. This study evaluated the utility of placenta derived mesenchymal stern cells (PDMSCs) seeded onto PCL-TCP scaffolds for bone tissue engineering Materials and Methods: PDMSCs were isolated from placenta. PCL-TCP scaffolds with PDMSCs were implanted in full-thickness mandibular bone defects (2x2 cm) in in impigs In the first experimental group, detects were treated with amnion-derived MSCs placed onto the scaffold, whereas in the second experimental group, defects were treated with deciduas-derived MSCs placed onto the scaffold. As a control, a third defect was treated with the scaffold only Histological and radiographic examinations were performed twelve weeks post-implantation Results: Soft radiographic measurements showed that experimental groups had twice the bone density of control group Experimental groups had a statistically significant increased bone regeneration potential compared to control group in mandibular bone defects in nunipies. Micro CT showed that experimental groups had higher levels of percent of regenerated volume fraction, regenerated bone volumes and regenerated bone surface than control group The histologic examination revealed the presence of regenerated bone at the central area of defect. Conclusion: PDMSCs seeded into the PCL TCP scaffolds enhance bone regeneration in mandibular defects Therefore PCL TCP scaffold with placenta derived mesenchymal stem eels can increase bone regeneration.
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- Appears in
Collections - 2. Clinical Science > Department of Dentistry > 1. Journal Articles
- 2. Clinical Science > Department of Oral and Maxillofacial Surgery > 1. Journal Articles
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