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Cited 15 time in webofscience Cited 21 time in scopus
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Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia

Authors
Kang, Seung-GulPark, Young-MinChoi, Jung-EunLim, Se-WonLee, Heon-JeongLee, Seung-HwanKim, Yong-KuKim, Seung-HyunCho, Sung NamKim, Leen
Issue Date
Jul-2010
Publisher
WILEY
Keywords
restless legs syndrome; antipsychotics; schizophrenia; monoamine A and B genes; polymorphism; gene-gene interaction
Citation
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, v.25, no.5, pp 397 - 403
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Volume
25
Number
5
Start Page
397
End Page
403
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14743
DOI
10.1002/hup.1130
ISSN
0885-6222
1099-1077
Abstract
Objective This study aimed to investigate whether the monoamine oxidase (MAO) A and B genes are associated with antipsychotic-induced restless legs syndrome (RLS) in schizophrenia. Methods We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients and divided the subjects into two groups: those with RLS symptoms (n=96) and those without RLS symptoms (n=94). Genotyping was performed for the variable number of tandem repeat (VNTR) polymorphism of the MAOA gene and A644G polymorphism of the MAOB gene. Results There was no significant difference in the genotype and allele frequencies of all polymorphisms investigated between these two groups. However, the result of global haplotype analysis showed a significant difference in haplotype frequencies between male subjects with and without RLS symptoms (p=0.013). The interaction between two polymorphisms had a significant effect on the RLS scores of both male (p=0.047) and female (p=0.028) patients. Conclusions These data do not suggest that the MAOA gene VNTR and MAOB gene A644G polymorphisms are associated with antipsychotic-induced RLS symptoms in schizophrenia. However, we found that the haplotype frequencies differed between the male schizophrenic patients with and without RLS symptom and the interaction between the two polymorphisms had a significant influence on the RLS scores of patients with schizophrenia. Copyright (C) 2010 John Wiley & Sons, Ltd.
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