Detailed Information

Cited 1 time in webofscience Cited 0 time in scopus
Metadata Downloads

Efficacy of Low Dose Proton Pump Inhibitor-Based Therapy to Eradicate Helicobacter pylori in Patients with Subtotal Gastrectomy

Authors
Kim, DongwooJung, Sung WooLee, Dong-wonLee, Chang MinKim, Seung YoungHyun, Jong JinJung, Young KulKoo, Ja SeolYim, Hyung JoonLee, Sang Woo
Issue Date
Nov-2019
Publisher
MDPI
Keywords
Helicobacter pylori; eradication; proton pump inhibitor
Citation
JOURNAL OF CLINICAL MEDICINE, v.8, no.11
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CLINICAL MEDICINE
Volume
8
Number
11
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1495
DOI
10.3390/jcm8111933
ISSN
2077-0383
Abstract
Proton pump inhibitor (PPI)-based therapy is standard to eradicate Helicobacter pylori (H. pylori). Gastric acidity is lowered after gastrectomy because of bile reflux and impaired mechanism of acid secretion. Therefore, low-dose PPI may be effective for H. pylori eradication in the remnant stomach after gastrectomy. In this study, we compared the efficacy of low-dose PPI with standard double-dose PPI to eradicate H. pylori in patients who underwent subtotal gastrectomy. A total of 145 patients who were treated for eradication after gastrectomy was analyzed. They were treated with PPI-based triple regimen (PPI, clarithromycin and amoxicillin) for 14 days. We compared the eradication rate in the low-dose PPI group (lansoprazole 15 mg once daily) with that in the standard double-dose PPI group (lansoprazole 30 mg twice daily). The H. pylori eradication rate was 79.1% in the low-dose PPI group and 85.3% in the standard double-dose group; the difference was not significant statistically (p = 0.357). In the multivariate analysis, low-dose PPI (odds ratio (OR) = 1.79, 95% confidence interval (CI), 0.68-4.69) was not associated with eradication failure, while Billroth II anastomosis (OR = 4.45, 85% CI, 1.23-16.2) was significantly associated with eradication failure. Low-dose PPI-based triple regimen was as effective as standard double-dose PPI-based regimen for H. pylori eradication in patients with subtotal gastrectomy. Further study is needed to confirm the effect of low-dose PPI on H. pylori eradication in patients with gastrectomy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Foregut Surgery > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jung, Sung Woo photo

Jung, Sung Woo
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE