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Cited 11 time in webofscience Cited 12 time in scopus
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Terlipressin-induced hyponatremic seizure

Authors
Hyun, Jong JinSeo, Yeon SeokLee, Kwang GyunKeum, BoraYim, Hyung JoonJeen, Yoon TaeChun, Hoon JaiUm, Soon HoKim, Chang DuckRyu, Ho Sang
Issue Date
Apr-2010
Publisher
TAYLOR & FRANCIS LTD
Keywords
Cirrhosis; hyponatremia; seizure; terlipressin; varix
Citation
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.45, no.4, pp 501 - 504
Pages
4
Indexed
SCI
SCIE
SCOPUS
Journal Title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume
45
Number
4
Start Page
501
End Page
504
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15023
DOI
10.3109/00365520903477355
ISSN
0036-5521
1502-7708
Abstract
Terlipressin is a splanchnic constrictor that is used to control variceal bleeding and is considered to have a very good safety profile compared to vasopressin. However, side effects such as hyponatremia and seizure, although very rare, can occur. Recently, the authors have experienced a case of hyponatremia induced by infusion of terlipressin which resulted in generalized seizure. On admission, the patient's sodium level was 141 mmol/1 but, 4 days after the initiation of terliprestin, it plummeted to 114 mmol/l, with serum osmolality also having fallen to 243 mOsm/kg. Hyponatremia could not be corrected despite correction with hypertonic saline but, after withdrawal of terlipressin, the serum sodium level showed a dramatic increase almost to the normal range the following day. Therefore, it is necessary to carefully monitor patients' electrolyte levels during the course of terlipressin therapy.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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