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Cited 9 time in webofscience Cited 12 time in scopus
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Dynamic changes in liver stiffness during the course of acute hepatitis A

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dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorLee, Kwang Gyun-
dc.contributor.authorJung, Eun Suk-
dc.contributor.authorAn, Hyonggin-
dc.contributor.authorPark, Sanghoon-
dc.contributor.authorKeum, Bora-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorJeen, Yoon Tae-
dc.contributor.authorChun, Hoon Jai-
dc.contributor.authorKim, Chang Duck-
dc.contributor.authorRyu, Ho Sang-
dc.contributor.authorUm, Soon Ho-
dc.date.available2020-11-03T06:47:59Z-
dc.date.issued2010-04-
dc.identifier.issn0036-5521-
dc.identifier.issn1502-7708-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15024-
dc.description.abstractObjective. Several recent studies have suggested that hepatic necroinflammation can alter the results of liver stiffness measurements (LSMs) obtained using the FibroScan device. However, the precise relationship between acute hepatic inflammation and LSMs remains unclear. The aim of this study was therefore to evaluate the dynamic changes in LSMs during the course of acute hepatic inflammation. Material and methods. Thirty-one patients with acute hepatitis A (AHA) were enrolled in this study (mean +/- SD age 29 +/- 7 years; 32.3% male). Only AHA patients who visited our hospital before their alanine aminotransferase (ALT) levels peaked were included. The day when AHA-associated symptoms began was considered as Day 0. Serum levels of ALT and bilirubin (BIL), and the international normalized ratio (rNR) were measured every 2 days, as were LSMs, until the peak levels of all parameters were identified. Subsequently, these parameters were measured every 1-2 weeks until they had normalized. Results. Peak serum levels of ALT and BIL, the INR, and LSMs were 3723 +/- 1513 IU/1, 5.8 +/- 2.4 mg/dl, 1.3 +/- 0.3, and 11.9 +/- 5.7 kPa, respectively. The time taken for LSMs to peak from Day 0 (8 +/- 2 days) differed significantly from that for ALT (5 +/- 1 days), BIL (10 +/- 4 days), and INR (5 +/- 1 days). LSMs had normalized (<= 5.5 kPa) in all patients at 34 +/- 17 days after Day 0. ALT level and the INR were significantly associated with peak LSMs and BIL level and the INR with the time taken for normalization of LSMs. Conclusions. LSMs changed dynamically during the course of AHA. The pattern of change appears to be related to the severity of hepatic necroinflammation.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherTAYLOR & FRANCIS LTD-
dc.titleDynamic changes in liver stiffness during the course of acute hepatitis A-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.3109/00365520903536515-
dc.identifier.scopusid2-s2.0-77949878063-
dc.identifier.wosid000276960000010-
dc.identifier.bibliographicCitationSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.45, no.4, pp 449 - 456-
dc.citation.titleSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY-
dc.citation.volume45-
dc.citation.number4-
dc.citation.startPage449-
dc.citation.endPage456-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusTRANSIENT ELASTOGRAPHY-
dc.subject.keywordPlusFIBROSIS-
dc.subject.keywordPlusBIOPSY-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusCIRRHOSIS-
dc.subject.keywordPlusVALUES-
dc.subject.keywordPlusGENDER-
dc.subject.keywordPlusSEX-
dc.subject.keywordAuthorElastography-
dc.subject.keywordAuthorinternational normalized ratio-
dc.subject.keywordAuthornecroinflammation-
dc.subject.keywordAuthoroverestimation-
dc.subject.keywordAuthorstiffness-
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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