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Cited 16 time in webofscience Cited 19 time in scopus
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IL-10 Mediates Rosiglitazone-Induced Kidney Protection in Cisplatin Nephrotoxicity

Authors
Kim, Myung-GyuYang, Ha NaKim, Hye-WonJo, Sang-KyungCho, Won YongKim, Hyoung-Kyu
Issue Date
Apr-2010
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Cisplatin Nephrotoxicity; Interleukin-10; PPAR Gamma Agonist
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.4, pp.557 - 563
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
25
Number
4
Start Page
557
End Page
563
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15040
DOI
10.3346/jkms.2010.25.4.557
ISSN
1011-8934
Abstract
Cisplatin, a major anti-neoplastic drug, is known to be nephrotoxic and inflammation-inducing. A peroxisome proliferator-activated receptor gamma agonist, regulating lipid metabolism, has known to have anti-inflammatory effect, but the protection mechanisms in various kidney injuries are not fully understood. The purpose of this study was to examine the reno-protective effect of rosiglitazone on cisplatin nephrotoxicity in mice focusing on inflammation and apoptosis. Male BALB/c mice were pretreated with rosiglitazone (10 mg/kg) or vehicle through daily intraperitoneal injection for 3 days and then were given a single injection of cisplatin (20 mg/kg). Cisplatin induced a significant rise in blood urea nitrogen and creatinine levels, and tubular cell damage with marked tissue inflammation. Tissue cytokines and chemokines measured by a cytometric bead array showed increased TNF-alpha, IL-6, MCP-1, and IFN-gamma levels, while IL-10, an anti-inflammatory cytokine, was significantly decreased by cisplatin treatment. However, rosiglitazone pretreatment substantially reversed the depressed IL-10 level with simultaneous suppression of proinflammatory cytokines and chemokines. This tissue cytokine and chemokine milieu was associated with marked attenuation of kidney injury elicited by cisplatin. These findings suggest that the rosiglitazone-mediated renoprotective effect in cisplatin nephrotoxicity of mice is partially mediated by upregulation of anti-inflammatory IL-10 production.
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Kim, Myung Gyu
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
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