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Usefulness of Non-invasive Markers for Predicting Significant Fibrosis in Patients with Chronic Liver Disease

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dc.contributor.authorLee, Han Hyo-
dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorUm, Soon Ho-
dc.contributor.authorWon, Nam Hee-
dc.contributor.authorYoo, Hanna-
dc.contributor.authorJung, Eun Suk-
dc.contributor.authorKwon, Yong Dae-
dc.contributor.authorPark, Sanghoon-
dc.contributor.authorKeum, Bora-
dc.contributor.authorKim, Yong Sik-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorJeen, Yoon Tae-
dc.contributor.authorChun, Hoon Jai-
dc.contributor.authorKim, Chang Duck-
dc.contributor.authorRyu, Ho Sang-
dc.date.available2020-11-03T06:51:36Z-
dc.date.issued2010-01-
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15241-
dc.description.abstractThe purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as >= F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, alpha 2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, alpha 2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherKOREAN ACAD MEDICAL SCIENCES-
dc.titleUsefulness of Non-invasive Markers for Predicting Significant Fibrosis in Patients with Chronic Liver Disease-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.3346/jkms.2010.25.1.67-
dc.identifier.scopusid2-s2.0-77949330366-
dc.identifier.wosid000273367200013-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.1, pp 67 - 74-
dc.citation.titleJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.citation.volume25-
dc.citation.number1-
dc.citation.startPage67-
dc.citation.endPage74-
dc.type.docTypeArticle-
dc.identifier.kciidART001407772-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusCHRONIC VIRAL-HEPATITIS-
dc.subject.keywordPlusSAMPLING VARIABILITY-
dc.subject.keywordPlusALANINE AMINOTRANSFERASE-
dc.subject.keywordPlusBIOPSY-
dc.subject.keywordPlusCIRRHOSIS-
dc.subject.keywordPlusINDEX-
dc.subject.keywordPlusRATIO-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusASPARTATE-
dc.subject.keywordPlusUTILITY-
dc.subject.keywordAuthorLiver Cirrhosis-
dc.subject.keywordAuthorBiological Markers-
dc.subject.keywordAuthorChronic Liver Disease-
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5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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