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골수 줄기세포와 주사형 MPEG-PCL diblock copolymer를 이용한 조직공학적 골재생Bone regeneration with injectable MPEG-PCL diblock copolymer and bone marrow mesenchymal stem cell
- Other Titles
- Bone regeneration with injectable MPEG-PCL diblock copolymer and bone marrow mesenchymal stem cell
- Issue Date
- 2010
- Publisher
- 대한악안면성형재건외과학회
- Keywords
- Injectable scaffold; MPEG-PCL diblock copolymer; Bone tissue engineering; BMP-2; Osteoblasts
- Citation
- Maxillofacial Plastic Reconstructive Surgery, v.32, no.1, pp 9 - 15
- Pages
- 7
- Journal Title
- Maxillofacial Plastic Reconstructive Surgery
- Volume
- 32
- Number
- 1
- Start Page
- 9
- End Page
- 15
- Abstract
- Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model. Materials and methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis. Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer. Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
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Related Researcher
- Rim, Jae Suk
- Guro Hospital (Department of Dentistry, Guro Hospital)