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Clinical courses after administration of oral corticosteroids in patients with severely cholestatic acute hepatitis A; three cases.

Authors
Yoon E.L.Yim H.J.Kim S.Y.Kim J.H.Lee J.H.Lee Y.S.Lee H.J.Jung S.W.Lee S.W.Choi J.H.
Issue Date
2010
Keywords
Acute hepatitis A; Cholestasis; Corticosteroid; Acute hepatitis A; Cholestasis; Corticosteroid
Citation
The Korean journal of hepatology, v.16, no.3, pp 329 - 333
Pages
5
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of hepatology
Volume
16
Number
3
Start Page
329
End Page
333
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15418
DOI
10.3350/kjhep.2010.16.3.329
ISSN
1738-222X
Abstract
Acute hepatitis A is currently outbreaking in Korea. Although prognosis of acute hepatitis A is generally favorable, a minority of patients are accompanied by fatal complications. Severe cholestasis is one of the important causes of prolonged hospitalization in patients with acute hepatitis A. In such cases, higher chances of additional complications and increased medical costs are inevitable. We report three cases of severely cholestatic hepatitis A, who showed favorable responses to oral corticosteroids. Thirty milligram of prednisolone was initiated and tapered according to the responses. Rapid improvement was observed in all cases without side effects. We suggest that corticosteroid administration can be useful in hepatitis A patients with severe cholestasis who do not show improvement by conservative managements. Clinical trial will be needed to evaluate effectiveness of corticosteroids in these patients.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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