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Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study.

Authors
Kwon O.S.Jung Y.K.Kim Y.S.Kim S.G.Kim Y.S.Lee J.I.Lee J.W.Kim Y.S.Chun B.C.Kim J.H.
Issue Date
2010
Keywords
Alcohol; Hepatocellular carcinoma; Hepatitis B virus; Cirrhosis
Citation
The Korean journal of hepatology, v.16, no.3, pp.308 - 314
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of hepatology
Volume
16
Number
3
Start Page
308
End Page
314
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15439
DOI
10.3350/kjhep.2010.16.3.308
ISSN
1738-222X
Abstract
Whether alcohol intake increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection remains controversial. The aim of this study was to determine the effect of alcohol intake on the development of HCC. Between January 2006 and August 2008, 146 patients with an initial diagnosis of HCC who were hospitalized in 3 major hospitals in the Incheon area were enrolled as cases. Another 146 cirrhotic patients, who matched the cases by age and sex, were enrolled as controls. All cases and controls were HBsAg positive, and had a history of lifetime alcohol intake. The cases and controls were aged 53±8 and 53±9 years (mean±SD), respectively, with each group comprising 118 males and 28 females. The basal laboratory data, distribution of Child-Pugh class, HBeAg positivity (31.5% vs. 37.7%), HBV DNA level (5.74±2.35 vs. 5.98±2.29 log10 copies/mL), and proportion with a lifetime alcohol intake of more than 292 kg (30.8% vs. 34.9%) did not differ between cases and controls. The cumulative alcohol intake and the proportion of heavy drinkers did not differ between the two groups in male patients. Alcohol intake might not increase the risk of HCC in patients with HBV infection.
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1. Basic Science > Department of Preventive Medicine > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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