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Radiation safety issues in Y-90 microsphere selective hepatic radioembolization therapy: Possible radiation exposure from the patients

Authors
Kim Y.-C.Kim Y.-H.Uhm S.-H.Seo Y.S.Park E.-K.Oh S.-Y.Jeong E.Lee S.Choe J.-G.
Issue Date
Dec-2010
Keywords
Hepatocellular carcinoma; Liver tumor; Radiation safety; Selective hepatic radio-embolization therapy; Y-90 microsphere
Citation
Nuclear Medicine and Molecular Imaging, v.44, no.4, pp.252 - 260
Indexed
SCOPUS
KCI
Journal Title
Nuclear Medicine and Molecular Imaging
Volume
44
Number
4
Start Page
252
End Page
260
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15444
DOI
10.1007/s13139-010-0047-7
ISSN
1869-3474
Abstract
Purpose: The purpose of this study was to estimate the possible external radiation dose to other individuals from patients treated with Y-90 resin microspheres for unresectable hepatocellular carcinoma. Methods: We designed the study prospectively to estimate the possible radiation dose to other individuals from patients who had been treated with Y-90 microspheres for unresectable hepatocellular carcinoma. We estimated the total effective dose equivalent (TEDE) using two methods: 'theoretical' TEDEs according to the administered activity and 'measured' TEDE based on the 'measured' ambient radiation exposure rate. We compared the results from each method to determine when we can release patients from confinement at the earliest time complying with the patient release criteria. Results: A total of 20 administrations of Y-90 resin microspheres were done in 18 patients. The average administered activity was 1.2±0.77 (0.28-2.97) GBq. The 'theoretical' TEDEs were in the range of 0.8-10 μSv. The 'measured' TEDEs were in the range of 2.31-185 μSv. The measured TEDEs tend to be higher than the theoretical TEDEs. The values of theoretical and measured TEDE were both far less than 1 mSv, the upper limit at which the licensee can release a patient without any written documents. Conclusion: The effective dose equivalent caused by the Y-90 microsphere administered patient is very low. It is safe in terms of radiation safety to the other individuals when Y-90 microsphere radioembolization therapy is done with dose less than 3 GBq. Because the measured TEDE tends to be higher than the theoretical TEDE, it is recommended to use 'measured' TEDE for determining patient release. © Korean Society of Nuclear Medicine 2010.
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2. Clinical Science > Department of Nuclear Medicine > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Radiology > 1. Journal Articles

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Choe, Jae Gol
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