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Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University
- Authors
- Ko G.J.; Zakaria A.; Womer K.L.; Rabb H.
- Issue Date
- 2010
- Keywords
- Acute kidney injury; Inflammation; Ischemia/reperfusion injury
- Citation
- Immunologic Research, v.47, no.1-3, pp 78 - 85
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Immunologic Research
- Volume
- 47
- Number
- 1-3
- Start Page
- 78
- End Page
- 85
- ISSN
- 0257-277X
1559-0755
- Abstract
- Abstracts: Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches. © 2010 Springer Science+Business Media, LLC.
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Related Researcher
- Ko, Gang Jee
- Guro Hospital (Department of Nephrology and Hypertension, Guro Hospital)