Titrated propofol induction vs. continuous infusion in children undergoing magnetic resonance imaging
- Authors
- Cho J.E.; Kim W.O.; Chang D.J.; Choi E.M.; Oh S.Y.; Kil H.K.
- Issue Date
- 2010
- Citation
- Acta Anaesthesiologica Scandinavica, v.54, no.4, pp 453 - 457
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Acta Anaesthesiologica Scandinavica
- Volume
- 54
- Number
- 4
- Start Page
- 453
- End Page
- 457
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15482
- DOI
- 10.1111/j.1399-6576.2009.02169.x
- ISSN
- 0001-5172
1399-6576
- Abstract
- Background: Propofol is the popular intravenous (i.v.) anaesthetic for paediatric sedation because of its rapid onset and recovery. We compared the efficacy and safety of a single dose and conventional infusion of propofol for sedation in children who underwent magnetic resonance imaging (MRI). Methods: This was a double-blind, randomized-controlled study. One hundred and sixty children were assigned to group I (single dose) or II (infusion). Sedation was induced with i.v. propofol 2 mg/kg, and supplemental doses of propofol 0.5 mg/kg were administered until adequate sedation was achieved. After the induction of sedation, we treated patients with a continuous infusion of normal saline at a rate of 0.3 ml/kg/h in group I and the same volume of propofol in group II. In case of inadequate sedation, additional propofol 0.5 mg/kg was administered and the infusion rate was increased by 0.05 ml/kg/h. Induction time, sedation time, recovery time, additional sedation and adverse events were recorded. Results: Recovery time was significantly shorter in group I compared with group II [0 (0-3) vs. 1 (0-3), respectively, P<0.001]. Group I (single dose) had significantly more patients with recovery time 0 compared with group II (infusion) (65/80 vs. 36/80, respectively, P<0.001). Induction and sedation times were not significantly different between groups. There was no significant difference in the frequency of additional sedation and adverse events between groups. Conclusion: A single dose of propofol without a continuous infusion can provide appropriate sedation in children undergoing MRI for <30 min. © 2009 The Acta Anaesthesiologica Scandinavica Foundation.
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- Appears in
Collections - 2. Clinical Science > Department of Anesthesiology and Pain Medicine > 1. Journal Articles
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