The utility of the human papillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia
- Authors
- So, Kyeong A.; Hong, Jin-Hwa; Hwang, Jong Ha; Song, Seung-Hun; Lee, Jae-Kwan; Lee, Nak Woo; Lee, Kyu Wan
- Issue Date
- Dec-2009
- Publisher
- KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
- Keywords
- Vaginal intraepithelial neoplasia; Human papillomavirus; Viral load
- Citation
- JOURNAL OF GYNECOLOGIC ONCOLOGY, v.20, no.4, pp 232 - 237
- Pages
- 6
- Indexed
- SCIE
SCOPUS
KCICANDI
- Journal Title
- JOURNAL OF GYNECOLOGIC ONCOLOGY
- Volume
- 20
- Number
- 4
- Start Page
- 232
- End Page
- 237
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15621
- DOI
- 10.3802/jgo.2009.20.4.232
- ISSN
- 2005-0380
2005-0399
- Abstract
- Objective: We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). Methods: A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology and HPV DNA test, and colposcopic biopsies were taken at 3- to 6-month intervals. Thirty-seven patients were followed for more than 6 months; their HPV DNA test results were compared to the cytology results for the prediction of disease prognosis. Results: The degree of VAIN was more severe in patients with a high initial HPV DNA load (p=0.009). Patients with VAIN 2 and VAIN 3 were older than those with VAIN 1 (p=0.005 and 0.008, respectively). In 26 out of 37 patients (70.3%), the VAIN resolved. The other patients had persistent lesions with no progression to invasive vaginal carcinoma. The last follow-up HPV DNA load was significantly higher in the group with persistent VAIN compared to the group with resolved VAIN (p<0.0001). Negative cytology was observed in 25 out of 26 patients in the VAIN resolved group and in nine out of 11 patients in the VAIN persistent group (p=0.205). Conclusion: These results suggest that the HPV DNA test, especially for viral load, was more effective for the diagnosis and prediction of persistent VAIN than cytology.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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