Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1 alpha mechanism
- Authors
- Kim, Sook Kyoung; Pak, Hui-Nam; Park, Jae Hyung; Choi, Jong Il; Nam, Myung-Hyun; Jo, Yunjung; Kim, Young-Hoon
- Issue Date
- Aug-2009
- Publisher
- OXFORD UNIV PRESS
- Keywords
- CD34+mononuclear cell; Atrial fibrillation; Catheter ablation; Cardiac injury
- Citation
- EUROPACE, v.11, no.8, pp 1024 - 1031
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPACE
- Volume
- 11
- Number
- 8
- Start Page
- 1024
- End Page
- 1031
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15878
- DOI
- 10.1093/europace/eup185
- ISSN
- 1099-5129
1532-2092
- Abstract
- Aims It has been known that myocardial ischaemia mobilizes CD34+ bone marrow-derived cells by the stromal cell-derived factor (SDF)-1 alpha pathway. We hypothesized that non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) recruits CD34+ cells by an alternative mechanism. Methods and results Fifty-six patients (39 males, 53.0 +/- 13.5 years old) who underwent electrophysiology study (EPS; n = 10) or RFCA of AF (n = 46) were included. Peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after, at 24 h, and 10 days after the procedure. The results are as follows: (i) the per cent increase in CD34+ cells (%Delta D34+) was significant after RFCA compared with after EPS (P < 0.01), and correlated with RF duration and troponin I, respectively. (ii) In contrast, SDF-1 alpha decreased after RFCA and had no correlation with %Delta CD34+ cells while matrix metalloproteinase (MMP)-9 (P < 0.0001) and GRO beta (P < 0.001) increased after RFCA and had correlations with 24 h %Delta CD34+ cells. Conclusion Non-ischaemic titrated cardiac injury caused by AF ablation mobilizes CD34+ cells to the peripheral blood through a non-SDF-1 alpha pathway associated with MMP-9 and GRO beta.
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- Appears in
Collections - 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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