Pretransplant Osteoporosis an'd Osteopenia are Risk Factors for Fractures After Kidney Transplantation
- Authors
- Lee, Eun Song; Lim, Jeong-Hoon; Cho, Jang-Hee; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Yong-Lim; Ro, Han; Lee, Sik; Han, Seung-Yeup; Jung, Cheol Woong; Park, Jae Berm; Kim, Myoung Soo; Yang, Jaeseok; Ahn, Curie; Kim, Chan-Duck
- Issue Date
- Oct-2019
- Publisher
- Appleton & Lange
- Citation
- Transplantation Proceedings, v.51, no.8, pp 2704 - 2709
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Transplantation Proceedings
- Volume
- 51
- Number
- 8
- Start Page
- 2704
- End Page
- 2709
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1593
- DOI
- 10.1016/j.transproceed.2019.03.071
- ISSN
- 0041-1345
1873-2623
- Abstract
- Background
There is a high risk of fracture after kidney transplantation (KT). Recipients of KT are susceptible to persistent hyperparathyroidism and other disorders of bone and mineral metabolism. However, the risk factors for fractures after KT remain uncertain. The aim of the present study was to investigate the risk factors for fracture after KT.
Methods
A total of 941 recipients of KT were enrolled from a multicenter observational cohort study in Korea from 2012 to 2016. The biochemical markers were measured at the time of KT, then annually for 5 years following KT. All fracture events were recorded. A Cox proportional hazards analysis was performed to calculate hazard ratios (HR) for the association of risk factors with fractures.
Results
Twenty-two fractures had occurred in 20 patients during the study period. Baseline and serial changes of mineral and bone biochemical markers were similar between fracture and nonfracture patient groups. Among the total study population, 104 patients were diagnosed with osteoporosis and 422 patients were diagnosed with osteopenia in a pretransplant bone mineral density test. In a multivariate Cox analysis, pretransplant osteoporosis (HR = 11.76; 95% confidence interval [CI], 2.28-60.69; P = .003) and pretransplant osteopenia (HR = 5.21; 95% CI, 1.15-23.57; P = .032) were independent risk factors for fracture in recipients of KT.
Conclusions
Pretransplant osteoporosis and osteopenia were independent risk factors for fracture after KT. More careful monitoring of bone mineral density before and after KT might be beneficial to predict the risk for fracture after KT.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Transplantation and Vascular Surgery > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.