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Cited 2 time in webofscience Cited 2 time in scopus
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Impact of Donor Age on the Outcomes of Kidney Transplantation From Deceased Donors With Histologic Acute Kidney Injury

Authors
Lim, KijoonLee, Yoo JinGwon, Jun GyoJung, Cheol WoongYang, JihyunOh, Se WonJo, Sang-KyungCho, Won YongKim, Myung-Gyu
Issue Date
Oct-2019
Publisher
ELSEVIER SCIENCE INC
Citation
TRANSPLANTATION PROCEEDINGS, v.51, no.8, pp.2593 - 2597
Indexed
SCIE
SCOPUS
Journal Title
TRANSPLANTATION PROCEEDINGS
Volume
51
Number
8
Start Page
2593
End Page
2597
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1596
DOI
10.1016/j.transproceed.2019.03.074
ISSN
0041-1345
Abstract
Purpose. Kidney transplantation from elderly donors with acute kidney injury (AKI) has increased recently due to donor shortage, but the safety and prognosis are not well known. We examined the effect of donor age on the outcomes of kidney transplantation (KT) from donors with histologic AKI. Materials and methods. We retrospectively analyzed the medical records of 59 deceased donor KTs with acute tubular necrosis (ATN) on preimplantation donor kidney biopsy between March 2012 and October 2017. Histologic evaluations of ATN, inflammation, glomerulosclerosis (GS), interstitial fibrosis, tubular atrophy, and arterial sclerosis were performed. Results. Twenty and 39 recipients received kidneys from elderly (> 60, 68.9 +/- 5.0 years) and young (<= 60, 45.9 +/- 9.6 years) donors with ATN, respectively. Among the elderly donors, significantly increased donor creatinine was observed in only 44% donors, and there were more diabetic patients and women and a higher proportion of GS than among the young donors. Six months after KT, estimated glomerular filtration rate was significantly lower in recipients who received kidneys from elderly donors compared to young donors. Donor creatinine level and AKI severity did not significantly affect the recipient outcomes in either group. However, the presence of ATN and GS were significant factors that exacerbated renal outcomes after KT from elderly donors only. On multivariate analysis, severe ATN was the strongest independent predictor of elderly recipient renal function. Conclusions. Histologic injury may predict renal outcomes in KT from elderly donors. A donor allocation protocol including preimplantation renal histology should be established for KT from elderly donors.
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2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
2. Clinical Science > Department of Transplantation and Vascular Surgery > 1. Journal Articles

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Jung, Cheol Woong
Anam Hospital (Department of Transplantation and Vascular Surgery, Anam Hospital)
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