Serum levels of YKL-40 and interleukin-18 and their relationship to disease severity in patients with preeclampsia
- Authors
- Seol, Hyun-Joo; Lee, Eun-Sung; Jung, So-Eun; Jeong, Nan-Hee; Lim, Ji-Eun; Park, Sung-Hoon; Hong, Soon-Cheol; Oh, Min-Jeong; Kim, Hai-Joong
- Issue Date
- Jan-2009
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Interleukin-18; Preeclampsia; YKL-40
- Citation
- JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v.79, no.2, pp 183 - 187
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Volume
- 79
- Number
- 2
- Start Page
- 183
- End Page
- 187
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16302
- DOI
- 10.1016/j.jri.2008.10.003
- ISSN
- 0165-0378
- Abstract
- Preeclampsia is a disease associated with the maternal inflammatory response. YKL-40 and interleukin-18 (IL-18) are inflammatory markers involved in inflammatory states and vascular processes. The aim of this study was to evaluate serum levels of YKL-40 and IL-18 in preeclampsia. Twenty-four patients with preeclampsia and 13 healthy pregnant women were included in this study. Serum levels of YKL-40 and IL-18 were measured using an enzyme-linked immunosorbent assay (ELISA). Serum YKL-40 levels were significantly higher in patients with preeclampsia (median 75.0 ng/mL; range 45.8-125.4 ng/mL) than in normal pregnant women (median 29.3 ng/mL; range 16.2-39.5 ng/mL; p = 0.000). Serum IL-18 levels were also significantly higher in patients with preeclampsia (median 159.9 pg/mL; range 125.6-193.5 pg/mL) than in normal pregnant women (median 120.2 pg/mL; range 102.2-157.9 pg/mL; p = 0.018). Notably, higher serum YKL-40 levels were observed in patients with more severe proteinuria (>= 3+ by dipstick) than in patients with milder proteinuria (<= 1+ by dipstick; median 121.3 ng/mL, range 63.5-146.7 ng/mL versus median 55.4 ng/mL, range 29.4-116.3 ng/mL; p = 0.022). There was, however, no significant difference in serum IL-18 levels between patients with more severe proteinuria and those with milder proteinuria. We conclude that circulating YKL-40 and IL-18 are elevated in patients with preeclampsia, and levels of YKL-40 are related to the severity of the disease. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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