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Cited 7 time in webofscience Cited 8 time in scopus
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Association of Angiotensin II Type 2 Receptor Gene A1818T Polymorphism with Progression of Immunoglobulin A Nephropathy in Korean Patientsopen access

Authors
Yoon, Hyung JinChin, Ho JunNa, Ki YoungChae, Dong-WanKim, SuhnggwonJeon, Un SilChung, Woo KyungLee, Hyun HeeYang, JaeseokKim, SejoongKwon, Young-JooKim, Hyun ChulPark, Sung BaeKim, Hye YoungLee, Tae Woo
Issue Date
Jan-2009
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Polymorphism; Single Nucleotide; Glomerulonephritis; IGA; Receptor; Angiotensin; Type 2
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, pp.S38 - S43
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
24
Start Page
S38
End Page
S43
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16305
DOI
10.3346/jkms.2009.24.S1.S38
ISSN
1011-8934
Abstract
We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) which was sponsored by the Korean Society of Nephrology. A1818T polymorphism of AT2R gene was analyzed with PCR-RFLP method and the association with the progression of IgAN, which was defined as over 50% increase in baseline serum creatinine level, was analyzed with survival analysis. Among the 480 patients followed for more than 10 months, the group without T allele had significantly higher rates of progression of IgAN than the group with T allele (11.4% vs. 3.9%, p=0.024), although there were no significant differences in the baseline variables such as initial serum creatinine level, the degree of proteinuria, and blood pressure. In the Cox's proportional hazard model, the hazard ratio of disease progression in the patients with T allele was 0.221 (95% confidence interval for Exp(B): 0.052-0.940, p=0.041) compared to that of without T allele. In conclusion, A1818T polymorphism of AT2R gene was associated with the progression of IgAN.
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Kwon, Young Joo
구로병원 (Department of Nephrology and Hypertension, Guro Hospital)
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