Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Safety of early chemotherapy after a laparoscopic colorectal cancer resection: A case-control study

Authors
Shin S.H.Lee S.-I.Choi D.-J.Woo S.-U.Kim J.Min B.-W.Moon H.-Y.Kim S.H.
Issue Date
2009
Keywords
Chemotherapy; Colorectal cancer; Laparoscopic resection; Safety
Citation
Journal of the Korean Society of Coloproctology, v.25, no.6, pp.429 - 436
Indexed
SCOPUS
KCI
Journal Title
Journal of the Korean Society of Coloproctology
Volume
25
Number
6
Start Page
429
End Page
436
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16482
DOI
10.3393/jksc.2009.25.6.429
ISSN
2093-7822
Abstract
Purpose: Since micrometastasis is generally inhibited by primary cancer, surgical ablation of the tumor may stimulate the growth of residual cancer cells, if they exist. This supports the importance of early administration of postoperative chemotherapy. Methods: We reviewed the cases of patients who underwent a laparoscopic resection and then received chemotherapy (5 fluorouracil+leucovorin or FOLFOX4) between September 2006 and May 2008. The chemotherapy was scheduled on the 7th or the 8th postoperative day, but was postponed when a final pathologic report was delayed or patients were discharged early. The safety of chemotherapy was evaluated in two ways. Early safety, such as the presence of surgical complications and medical toxicity, was prospectively assessed just before the beginning of the second cycle of chemotherapy. Late safety, such as medical toxicity, was retrospectively estimated from the 2nd to the last cycle. These safeties were compared between the two groups: the early chemotherapy group (n=50) for which chemotherapy started on the 7th or 8th postoperative day as scheduled and the delayed chemotherapy group (n=31) for which chemotherapy started after the 14th postoperative day. Results: Patient demographics were not different between the two groups. With regards to early safety, no differences in surgical complications existed between the two groups. In medical toxicities, there were no differences, except for a higher rate of nausea in the early chemotherapy group (20 percent vs. 10 percent, P=0.01). With regards to late safety, the two groups were not different in the development of medical toxicities. Conclusion: Because nausea is an easily controllable toxicity, we conclude that chemotherapy is safely started on the 7th or the 8th day after a laparoscopic colorectal cancer resection. ©2009 The Korean Society of Coloproctology.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Jin photo

Kim, Jin
Anam Hospital (Department of Colon and Rectal Surgery, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE