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No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients
- Authors
- Kang, Seung-Gul; Choi, Jung-Eun; An, Hyonggin; Lim, Se-Won; Lee, Heon-Jeong; Han, Changsu; Kim, Yong-Ku; Kim, Seung-Hyun; Cho, Sung Nam; Lee, Min-Soo; Joe, Sook-Haeng; Jung, In-Kwa; Kim, Leen
- Issue Date
- 1-Aug-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- brain-derived neurotrophic factor; polymorphism; schizophrenia; tardive dyskinesia
- Citation
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.32, no.6, pp 1545 - 1548
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Volume
- 32
- Number
- 6
- Start Page
- 1545
- End Page
- 1548
- ISSN
- 0278-5846
1878-4216
- Abstract
- Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. Results: The frequencies of genotypes (chi(2)=2.37, p=0.306) and alleles (chi(2)=0.03. p=0.867) did not differ significantly between these two groups. Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. Crown Copyright (C) 2008 Published by Elsevier Inc. All rights reserved.
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Related Researcher
- An, Hyong gin
- College of Medicine (Department of Biostatistics)