Predictive Factors and Survival Rate for Brain Metastasis from Breast Cancer
- Authors
- Lee, Jung Ah; Bae, Jeoung Won; Woo, Sang Uk; Lee, Jae Bok; Koo, Byum Whan
- Issue Date
- Jun-2008
- Publisher
- KOREAN BREAST CANCER SOC
- Keywords
- Breast cancer; Brain metastases; Predictive factor; Survival
- Citation
- JOURNAL OF BREAST CANCER, v.11, no.2, pp 71 - 76
- Pages
- 6
- Indexed
- SCIE
SCOPUS
KCICANDI
- Journal Title
- JOURNAL OF BREAST CANCER
- Volume
- 11
- Number
- 2
- Start Page
- 71
- End Page
- 76
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16962
- DOI
- 10.4048/jbc.2008.11.2.71
- ISSN
- 1738-6756
2092-9900
- Abstract
- Purpose: The incidence of symptomatic brain metastases from breast cancerhas ranged from 10% to 16%. Brain metastases are traditionally viewed as a late complication of systemic disease, for which few effective treatment options exist. The aim of this study was to evaluate the factors that can predict brain metastases and to analyze the survival rate as compared with other systemic metastases. Methods: Between February 1983 and October 2005, 119 patient who developed systemic metastasis during the follow up period after optimal surgical treatment at Korea University Hospital were included in this study. Twenty-nine of these 119 patients had complaints of symptoms and they were consequently diagnosed as having brain metastases. Results: Estrogen receptor (-), progesterone receptor (-) and Her2 (-), and Triple negative were a significantly higher in the patients with brain metastases (p=0.04). The other clinicopathologic factors showed no difference between the patients with brain metastases and the patients without brain metastases. Lung metastases existed previously more often than the other systemic metastases (p=0.04). The overall survival of the patients with brain metastases was not significantly different from the patients with other systemic metastases. However, the disease specific survival of patients with brain metastases, as compared with other systemic metastases was poorer than that for patients with bone and lung metastases, respectively (p=0.01 and 0.03). A poor prognosis was shown for the cases with brain metastases within 1 yr after operation. Conclusion: Clinician should give attention to the possibility of brain metastases for the breast cancer patients with triple negative findings or the patients who have developed lung metastases as this represents a symptom of central nervous system.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Breast and Endocrine Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Anesthesiology and Pain Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.