Apolipoprotein B is a better marker than non-HDL-cholesterol for the metabolic syndrome in Koreans
- Authors
- Han, Jee Hye; Park, Hye Soon; Kim, Jeong A.; Kim, Seon Mee
- Issue Date
- Mar-2008
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- apolipoprotein B; non-HDL-cholesterol; metabolic syndrome; prediction; Korean
- Citation
- ATHEROSCLEROSIS, v.197, no.1, pp 333 - 338
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- ATHEROSCLEROSIS
- Volume
- 197
- Number
- 1
- Start Page
- 333
- End Page
- 338
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17140
- DOI
- 10.1016/j.atherosclerosis.2007.05.021
- ISSN
- 0021-9150
1879-1484
- Abstract
- Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. Non-HDL-cholesterol (non-HDL-C) has been considered a therapeutic target for patients with hypertriglyceridemia. We compared the predictive values of apoB and non-HDL-C for the metabolic syndrome (MetS) in 3335 Korean adults (mean age, 45.2 years) who participated consecutively in a health examination in a university hospital. Anthropometry, blood pressure, fasting glucose, lipid profiles and apoB were measured. MetS, as defined by a modification of the NCEP-ATP III criteria, was present in 22.1% of men and 16.1% of women. Among the components of the MetS, triglycerides showed the strongest correlation with apoB (r = 0.393, P < 0.001 in men, and r = 0.326, P < 0.001 in women) and non-HIDL-C (r = 0.376, P < 0.001 in men, and r = 0.349, P < 0.001 in women). When apoB and non-HDL-C were mutually adjusted, the ORs for the MetS of non-HDL-C were not significant. As a function of the quartile of apoB levels, the ORs for the MetS were 2.04 (1.26-3.30), 3.54 (2.11-5.93), and 5.38 (3.16-9.17) in men (P for trend <0.001) and 3.75 (1.42-9.87),5.55 (2.09-14.69), and 13.41 (5.02-35.79)in women (P for trend <0.001), respectively. These findings indicate that apoB is a better marker than non-HDL-C for identifying the MetS among Koreans. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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Collections - 2. Clinical Science > Department of Family Medicine > 1. Journal Articles
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