Radiofrequency ablation of high-grade dysplastic nodules in chronic liver disease: Comparison with well-differentiated hepatocellular carcinoma based on long-term results
- Authors
- Kim S.H.; Lim H.K.; Kim M.J.; Choi D.; Rhim H.; Park C.K.
- Issue Date
- 2008
- Keywords
- High-grade dysplastic nodule; Radiofrequency ablation; Survival; Well-differentiated hepatocellular carcinoma
- Citation
- European Radiology, v.18, no.4, pp 814 - 821
- Pages
- 8
- Indexed
- SCOPUS
- Journal Title
- European Radiology
- Volume
- 18
- Number
- 4
- Start Page
- 814
- End Page
- 821
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17469
- DOI
- 10.1007/s00330-007-0823-7
- ISSN
- 0938-7994
1432-1084
- Abstract
- This retrospective study compared the long-term results of percutaneous radiofrequency (RF) ablation for high-grade dysplastic nodules (DNs) and well-differentiated hepatocellular carcinomas (HCCs). Between April 1999 and December 2006, 20 patients with 21 high-grade DNs (range, 1.2-3.0 cm; mean, 1.9 cm) (group 1) and 49 with a well-differentiated HCC (range, 1.0-5.0 cm; mean, 2.3 cm) (group 2) underwent RF ablation. The technique effectiveness, local tumor progression, cancer-free and cumulative survivals using the Kaplan-Meier method were compared. The technique effectiveness rates at 1 year after RF ablation were 100% (19/ 19) and 94.1% (32/34) in groups 1 and 2, respectively (P>0.05). The local tumor progression rates in groups 1 and 2 were 0% and 20.6% (7/ 34), respectively (P=0.041). The local tumor progression in group 2 was seen on follow-up computed tomography 4-58 months (mean, 17 months) after RF ablation. The 1-, 3-, and 5-year cancer-free survival rates in groups 1 and 2 were 95.0% and 76.9%, 56.2% and 44.6%, and 38.5% and 24.8%, respectively (P>0.05). The 1-, 3-, and 5-year cumulative survival rates in groups 1 and 2 were 100% and 97.9%, 73.0% and 68.0%, and 63.8% and 51.1%, respectively (P>0.05). Percutaneous RF ablation is effective for treating high-grade DNs and well-differentiated HCCs. The long-term results after RF ablation of high-grade DNs may be improved compared with those of well-differentiated HCCs. © European Society of Radiology 2007.
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Collections - 2. Clinical Science > Department of Radiology > 1. Journal Articles
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