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Technique for the early detection of drug-resistant HBV DNA during antiviral therapy
- Authors
- Yeon, Jong Eun
- Issue Date
- 2008
- Publisher
- KARGER
- Keywords
- antiviral drug resistance; HBV; laser desorption/ionization; mass spectrometry analysis; resistant mutants
- Citation
- INTERVIROLOGY, v.51, pp 7 - 10
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERVIROLOGY
- Volume
- 51
- Start Page
- 7
- End Page
- 10
- ISSN
- 0300-5526
1423-0100
- Abstract
- Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed. Copyright c 2008 S. Karger AG, Basel.
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Related Researcher
- Yeon, Jong Eun
- Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)