Persistent anemia in a patient with diffuse large B cell lymphoma: Pure red cell aplasia associated with latent Epstein-Barr virus infection in bone marrow
- Authors
- Sung, Hwa Jung; Kim, Seok Jin; Lee, Ji-Hye; Lee, Goeun; Lee, Kyung A.; Choi, Chul Won; Kim, Byung Soo; Kim, Jun Suk
- Issue Date
- Sep-2007
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- red-cell aplasia; Epstein-Barr virus; lymphoma
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.22, pp S167 - S170
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 22
- Start Page
- S167
- End Page
- S170
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17763
- DOI
- 10.3346/jkms.2007.22.S.S167
- ISSN
- 1011-8934
1598-6357
- Abstract
- We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma. Persistent anemia without an obvious cause was observed in a 47-yr-old man diagnosed with relapsed diffuse large B cell lymphoma. The bone marrow study showed only erythroid hypoplasia without the evidence of bone marrow involvement with lymphoma cells, thus PRCA was suggested. However, parvovirus infection was excluded as a potential cause of PRCA because of negative IgM anti-parvovirus B19 antibody and negative parvovirus PCR in the serum. Latent Epstein-Barr virus (EBV) infection of bone marrow was suggested by in situ hybridization with EBV-encoded small RNA (EBER) that showed a strong positive expression in bone marrow cells. Thus, PRCA was thought to be associated with latent EBV infection in bone marrow cells. Although the finding of unexplained anemia is a possible predictor of bone marrow involvement with lymphoma cells, PRCA as a result of a viral infection including EBV should be considered in lymphoma patients. This is the first report of the occurrence of PRCA associated with latent EBV infection in a patient with non-Hodgkin's lymphoma.
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Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
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