Levels of hepatitis B virus (HBV) replication during the nonreplicative phase: HBV quantification by real-time PCR in Korea
- Authors
- Yim, Hyung Joon; Byun, Kwan Soo; Chang, Yun Jung; Suh, Yeon Seok; Yeon, Jong Eun; Lee, Chang Hong; Kwon, Jung Ah; Yoo, Wangdon; Kim, Soo-Ok; Hong, Sun Pyo
- Issue Date
- Sep-2007
- Publisher
- Kluwer Academic/Plenum Publishers
- Keywords
- nonreplicative phase; inactive HBsAg carriers; HBsAg loss; hepatitis B virus DNA; real-time PCR
- Citation
- Digestive Diseases and Sciences, v.52, no.9, pp 2403 - 2409
- Pages
- 7
- Indexed
- SCOPUS
- Journal Title
- Digestive Diseases and Sciences
- Volume
- 52
- Number
- 9
- Start Page
- 2403
- End Page
- 2409
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17781
- DOI
- 10.1007/s10620-006-9140-2
- ISSN
- 0163-2116
1573-2568
- Abstract
- The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P < 0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6x10(4) copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.
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- Appears in
Collections - 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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