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Cited 2 time in webofscience Cited 3 time in scopus
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Levels of hepatitis B virus (HBV) replication during the nonreplicative phase: HBV quantification by real-time PCR in Korea

Authors
Yim, Hyung JoonByun, Kwan SooChang, Yun JungSuh, Yeon SeokYeon, Jong EunLee, Chang HongKwon, Jung AhYoo, WangdonKim, Soo-OkHong, Sun Pyo
Issue Date
Sep-2007
Publisher
Kluwer Academic/Plenum Publishers
Keywords
nonreplicative phase; inactive HBsAg carriers; HBsAg loss; hepatitis B virus DNA; real-time PCR
Citation
Digestive Diseases and Sciences, v.52, no.9, pp.2403 - 2409
Indexed
SCOPUS
Journal Title
Digestive Diseases and Sciences
Volume
52
Number
9
Start Page
2403
End Page
2409
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17781
DOI
10.1007/s10620-006-9140-2
ISSN
0163-2116
Abstract
The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P < 0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6x10(4) copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.
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2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Yeon, Jong Eun
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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