The relationship between cytokines and HPV-16, HPV-16 E6, E7, and high-risk HPV viral load in the uterine cervix
- Authors
- Song, Seung-Hun; Lee, Jae-Kwan; Seok, Oye-Sun; Saw, Ho-Suk
- Issue Date
- Mar-2007
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- human papillomavirus (HPV); interleukin-6 (IL-6); interleukin-10 (11-10); tumor necrosis factor alpha (TNF-alpha); Interferon-gamma (IFN-gamma)
- Citation
- GYNECOLOGIC ONCOLOGY, v.104, no.3, pp 732 - 738
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- GYNECOLOGIC ONCOLOGY
- Volume
- 104
- Number
- 3
- Start Page
- 732
- End Page
- 738
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18071
- DOI
- 10.1016/j.ygyno.2006.10.054
- ISSN
- 0090-8258
1095-6859
- Abstract
- Objectives. To investigate intralesional cytokine levels in precancerous lesions of the uterine cervix and their relationship with human papillomavirus (HPV) type 16, HPV type 16 E6/E7, and high-risk HPV viral load. Methods. We performed a prospective study of 67 patients between May 2005 and December 2005. Hybrid Capture 11 testing was used to identify patients as high-risk HPV DNA-positive or -negative. HPV DNA Chip test was performed for HPV genotyping in all cases found to be HPV DNA-positive. Real-time PCR was used to quantify HPV-16 E6, E7, interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) transcripts. Results. Among high-risk HPV-infected women, intralesional TNF-alpha, IL-6, IL-10, and IFN-gamma levels had no significant differences according to histologic grade. In multivariate logistic regression analysis, TNF-alpha, IL-6, IL-10, and IFN-gamma were not associated with HPV-16. Increased IFN-gamma was significantly associated with HPV-16 E6- and E7-positive (OR 28.197, 95% Cl: 2.658-299.110; OR 19.617, 95% Cl: 2.135-180.253, respectively), whereas TNF-alpha, IL-6, and IL-10 were not associated with HPV- 16 E6 and ET In multiple regression analysis, elevated IFN-gamma was significantly associated with increased HPV viral load (P=0.039), whereas TNF-alpha, IL-6, and IL-10 were not significantly associated with HPV viral load. Conclusions. Among HPV-infected women, IFN-gamma is significantly associated with HPV- 16 E6, E7, and high-risk HPV viral load in the uterine cervix. Thus, increased intralesional TFN-gamma may be considered to be a prognostic marker for oncogenic potential of high-risk HPV (c) 2006 Elsevier Inc. All rights reserved.
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Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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