Detailed Information
Cited 4 time in 
Cited 5 time in 
Cited 5 time in
Metadata Downloads
Phospholipase C gamma 1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade
- Authors
- Shin, Soon Young; Choi, Ha Young; Ahn, Bong-Hyun; Min, Do Sik; Son, Sang Wook; Lee, Young Han
- Issue Date
- 16-Feb-2007
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- PLC gamma 1; MMP-3; protein kinase C; MAPK
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.353, no.3, pp 611 - 616
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 353
- Number
- 3
- Start Page
- 611
- End Page
- 616
- ISSN
- 0006-291X
1090-2104
- Abstract
- The phospholipid hydrolase phospholipase C71 (PLC gamma 1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLC gamma 1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLC gamma 1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLC gamma 1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors. (c) 2006 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Dermatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Son, Sang Wook
- Ansan Hospital (Department of Dermatology, Ansan Hospital)