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Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction
- Authors
- Kim G.-W.; Choi Y.-J.; Kim M.-S.; Park Y.; Lee K.-B.; Kim I.-S.; Hwang S.-J.; Noh I.
- Issue Date
- 2007
- Keywords
- Evaluation; Hyaluronic acid; In situ hydrogel; Poly(ethylene oxide)
- Citation
- Current Applied Physics, v.7, no.SUPPL.1, pp e28 - e32
- Indexed
- SCOPUS
KCICANDI
- Journal Title
- Current Applied Physics
- Volume
- 7
- Number
- SUPPL.1
- Start Page
- e28
- End Page
- e32
- ISSN
- 1567-1739
1878-1675
- Abstract
- Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups. © 2006 Elsevier B.V. All rights reserved.
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Collections - 1. Basic Science > Department of Biomedical Engineering > 1. Journal Articles
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Related Researcher
- Park, Yong doo
- College of Medicine (Department of Biomedical Engineering)