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Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor
- Authors
- Shin E.-J.; Chae J.S.; Jung M.-E.; Bing G.; Ko K.H.; Kim W.-K.; Wie M.B.; Cheon M.-A.; Nah S.-Y.; Kim H.-C.
- Issue Date
- 2007
- Keywords
- α7 nicotinic acetylcholine receptor; AP-1 DNA binding activity; Hippocampus; Kainic acid; Neuroprotection; Nicotine
- Citation
- Epilepsy Research, v.73, no.3, pp 292 - 298
- Pages
- 7
- Indexed
- SCOPUS
- Journal Title
- Epilepsy Research
- Volume
- 73
- Number
- 3
- Start Page
- 292
- End Page
- 298
- ISSN
- 0920-1211
1872-6844
- Abstract
- We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity. © 2006 Elsevier B.V. All rights reserved.
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Collections - 1. Basic Science > Department of Neuroscience > 1. Journal Articles
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Related Researcher
- Kim, Won Ki
- College of Medicine (Department of Neural Sciences)