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Cited 9 time in webofscience Cited 12 time in scopus
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Association between monoamine oxidase a Polymorphisms and anger-related personality traits in Korean women

Authors
Yang, Jae-WonLee, So-HeeRyu, Seung-HoLee, Boung-ChulKim, Seung-HyunJoe, Sook-HaengJung, In-KwaChoi, Ihn-GeunHam, Byung-Joo
Issue Date
2007
Publisher
KARGER
Keywords
anger-related behavior; monoamine oxidase a gene; polymorphism
Citation
NEUROPSYCHOBIOLOGY, v.56, no.1, pp.19 - 23
Indexed
SCIE
SCOPUS
Journal Title
NEUROPSYCHOBIOLOGY
Volume
56
Number
1
Start Page
19
End Page
23
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18430
DOI
10.1159/000109973
ISSN
0302-282X
Abstract
It has been suggested that polymorphisms in the monoamine oxidase A ( MAO-A) gene are associated with aggressive and impulsive behaviors. In the present study, we investigated the association of the MAO-A variable number of tandem repeat polymorphism in the promoter region (MAO-A uVNTR) with anger-related personality traits. Specifically, MAO-A uVNTR polymorphisms were examined for associations with the State-Trait Anger Expression Inventory (STAXI) scores in 211 normal Korean women. All subjects were assessed using the STAXI and genotyped for MAO-A uVNTR status. The scores on the STAXI subscales differed significantly among the MAO-A uVNTR polymorphism genotypes in terms of anger expression-out (AX-Out) scores. Post hoc comparisons revealed significant differences between the 3/3 and 4/4, and between 3/4 and 4/4 polymorphisms. However, no significant difference was observed in other STAXI subscale scores among these genotypes. Subjects with the high-activity MAO-A uVNTR had significantly higher AX-Out scores than subjects with other genotypes. MAO-A uVNTR polymorphisms may contribute in part to the expression of anger. These findings support the hypothesis that this polymorphism in the MAO-A gene may be associated with anger-related personality traits in Korean women. Copyright (c) 2007 S. Karger AG, Basel.
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Ham, Byung Joo
Anam Hospital (Department of Psychiatry, Anam Hospital)
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