Association between monoamine oxidase a Polymorphisms and anger-related personality traits in Korean women
- Authors
- Yang, Jae-Won; Lee, So-Hee; Ryu, Seung-Ho; Lee, Boung-Chul; Kim, Seung-Hyun; Joe, Sook-Haeng; Jung, In-Kwa; Choi, Ihn-Geun; Ham, Byung-Joo
- Issue Date
- 2007
- Publisher
- KARGER
- Keywords
- anger-related behavior; monoamine oxidase a gene; polymorphism
- Citation
- NEUROPSYCHOBIOLOGY, v.56, no.1, pp 19 - 23
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROPSYCHOBIOLOGY
- Volume
- 56
- Number
- 1
- Start Page
- 19
- End Page
- 23
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18430
- DOI
- 10.1159/000109973
- ISSN
- 0302-282X
1423-0224
- Abstract
- It has been suggested that polymorphisms in the monoamine oxidase A ( MAO-A) gene are associated with aggressive and impulsive behaviors. In the present study, we investigated the association of the MAO-A variable number of tandem repeat polymorphism in the promoter region (MAO-A uVNTR) with anger-related personality traits. Specifically, MAO-A uVNTR polymorphisms were examined for associations with the State-Trait Anger Expression Inventory (STAXI) scores in 211 normal Korean women. All subjects were assessed using the STAXI and genotyped for MAO-A uVNTR status. The scores on the STAXI subscales differed significantly among the MAO-A uVNTR polymorphism genotypes in terms of anger expression-out (AX-Out) scores. Post hoc comparisons revealed significant differences between the 3/3 and 4/4, and between 3/4 and 4/4 polymorphisms. However, no significant difference was observed in other STAXI subscale scores among these genotypes. Subjects with the high-activity MAO-A uVNTR had significantly higher AX-Out scores than subjects with other genotypes. MAO-A uVNTR polymorphisms may contribute in part to the expression of anger. These findings support the hypothesis that this polymorphism in the MAO-A gene may be associated with anger-related personality traits in Korean women. Copyright (c) 2007 S. Karger AG, Basel.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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