Risk factors for the progression or persistence of untreated mild dysplasia of the uterine cervix
- Authors
- Song, S. -H.; Lee, J. -K.; Oh, M. -J.; Hur, J. -Y.; Park, Y. -K.; Saw, H. -S.
- Issue Date
- Jul-2006
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- HPV; mild dysplasia; persistence; progression; viral load
- Citation
- INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, v.16, no.4, pp 1608 - 1613
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Volume
- 16
- Number
- 4
- Start Page
- 1608
- End Page
- 1613
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18761
- DOI
- 10.1111/j.1525-1438.2006.00634.x
- ISSN
- 1048-891X
1525-1438
- Abstract
- To identify the factors that may predict the progression or persistence of untreated mild dysplasia of the uterine cervix, we performed a retrospective review of 118 patients with histologically verified mild dysplasia who underwent colposcopic biopsies between January 1999 and December 2003. Regression to normal occurred in 70.3%, progression to moderate dysplasia or worse occurred in 11.0%, and persistence of mild dysplasia occurred in 18.7%. In regression/progression analysis, progression of untreated mild dysplasia was 34.5% (10/29) in patients with high viral loads (>= 100 relative light units/positive control [RLU/PC]) and 4.5% (3/67) in those with low viral loads (1 to < 100 RLU/PC) and negative human papillomavirus (HPV) tests (P < 0.001). Women with high viral loads had a 13-fold greater chance of progression of untreated mild dysplasia than those with low viral loads and negative HPV tests (CI: 2.494-95.297; P = 0.0022). Those associated with both positive smear and positive HPV test (12/45 = 26.7%) were at a greater risk of progression of untreated mild dysplasia as compared with those with positive smear and negative HPV (0/17 = 0.0%) or those with negative smear and positive HPV test (1/18 = 5.6%). Those with high viral loads and both with positive smear and positive HPV test should be followed closely because of their increased risk of progression of untreated mild dysplasia.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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