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No borna disease virus-specific RNA detected in blood of race horses and jockeys
- Authors
- Kim, Yong-Ku; Noh, Kyung-Bo; Han, Chang-Su; Moon, Ju-Young; Yoon, Do-Kyung; Song, Ki-Joon; Kim, Dai-Jin; Kubera, Marta; Maes, Michael; Song, Jin-Won
- Issue Date
- Jun-2006
- Publisher
- CAMBRIDGE UNIV PRESS
- Keywords
- BDV; horse; jockey; PCR; psychiatric disorder
- Citation
- ACTA NEUROPSYCHIATRICA, v.18, no.3-4, pp 177 - 180
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA NEUROPSYCHIATRICA
- Volume
- 18
- Number
- 3-4
- Start Page
- 177
- End Page
- 180
- ISSN
- 0924-2708
1601-5215
- Abstract
- Background: Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders. Objectives: We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses. Methods: We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription-polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts. Results: The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys. Conclusions: These data do not support an epidemiological association between BDV infection, race horses and humans.
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Related Researcher
- Song, Ki Joon
- College of Medicine (Department of Microbiology)